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. 2004 Mar;78(6):2722–2728. doi: 10.1128/JVI.78.6.2722-2728.2004

FIG. 1.

FIG. 1.

Sensitivity of early R3R5X4/R5X4 and late R3X4/X4 HIV-1 variants to CXCR4 antagonists in the MT2 T-cell line. (A) Sensitivity to the CXCR4-specific bicyclam AMD3100. (B) Sensitivity to CXCR4-specific MAbs. The virus variants from patient ACH208 that were used (left side) were early R5X4 (12.F4 and 13.B1) and late X4 (X1.A1 and X1.B1); those from patient ACH039 (right side) were early R3R5X4 (20.B10 and 20.C6) and late R3X4 (X1.C4 and X1.H4). Percent inhibition relative to control infections was calculated. Experiments were performed in triplicate, and average values are shown. A representative graph of at least two independent experiments is shown. Open symbols indicate early R5X4 or R3R5X4 variants; filled symbols indicate late R3X4 or X4 variants.