TABLE 1.
Characteristics of X4 HIV-1 variants
| Patient | Serologic statuse | Early virus variants
|
Late virus variants
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Time to seroconversion or entry (mo)a | Time to X4 (mo)a | Coreceptor usageb | CD4 T-cell count (cells/μl) | RNA load (log no. of copies/ml) | n | Time to seroconversion or entry (mo) | Time to X4 (mo) | Coreceptor usageb | CD4 T-cell count (cells/μl) | RNA load (log no. of copies/ml) | ||
| ACH208 | Sc | 3 | 18.5 | 4.5 | R5X4 (2) | 440 | 4.4 | 5 | 64.1 | 50.1 | X4 (5) | 30 | NAf |
| X4 (1) | |||||||||||||
| ACH039 | Sc | 6 | 18.0 | 1.9 | R3R5X4 (3) | 570 | 4.7 | 5 | 48.5 | 32.4 | R3X4 (5) | 10 | NA |
| X4d (3) | |||||||||||||
| ACH0171 | Sc | 4 | 66.8 | 5.2 | R3R5X4 (3) | 380 | 4.9 | 4 | 89.3 | 27.0 | R3R5X4 (1) | 130 | 5.4 |
| X4 (1) | X4 (3) | ||||||||||||
| ACH1120 | Sc | 5 | 53.1 | 7.3 | X4d | 270 | 6.4 | 4 | 66.2 | 20.4 | X4d | 10 | NA |
| ACH6052 | Sp | 5 | 0c | —c | X4d | 500 | NA | 5 | 32.0 | —c | X4d | 20 | NA |
a
When virus variants from multiple time points were analyzed, the average time to seroconversion or first detection of X4 HIV-1 variants is given.
b
The absolute number of virus variants with the indicated coreceptor preference in transfected U87 cells is given in parentheses. Data are available from a previous study (45).
c
Patient ACH6052 was seropositive and carried X4 variants at the time of entry into the cohort. No estimated time of first detection of X4 HIV-1 variants can therefore be given.
d
CXCR4 usage for entry as determined in MT2 cell line and replication in CCR5Δ/Δ PBMC. Other coreceptor preferences in transfected U87 cells were not tested.
e
Sc, seroconverter; Sp, seroprevalent.
f
NA, not available.