Fig. 4.

Assessment of natural processing of immunogenic peptides tested in HHD II mice

HHD II mice were immunized by the gene gun with L. major/L. mexicana gp63 three times. After a week of the last immunization mice were killed and the CTL activity was determined by standard 4-hour cytotoxicity assay. Graphs represent 6 immunized mice for each peptide tested in three independent experiments. A: mouse immunized with C2 peptide B: mouse immunized with CM4 peptide. Graphs represent a number of independent positive experiments as Table 3