Fig. 10.

In the spleen of mice infected with malaria, the red and white pulp elements were enlarged accompanied by the lost of typical structure of the germinal centre (B), which is comparable to the normal uninfected mice (A). Accumulation of malarial pigments, haemozoin, was obvious in the pulp histiocytes and sinusoidal lining cells (C). Microvascular sequestrations of PRBCs were also present (D). Viewed under light microscopy at 100x (A & B) and 400x (C & D) magnification