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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Immunol. 2012 Aug 1;189(5):2614–2624. doi: 10.4049/jimmunol.1200495

Figure 5. PPARγ is critical to preserve lung macrophage cellular homeostasis.

Figure 5

(A) Cellular lipid levels were assessed in resting lung macrophages from LysM-Cre × PPARγflox/flox mice (PPARγΔMac/PMN) and controls (CTRL) using Bofipy-FL staining (n=3 mice per group). (B) mRNA expression of genes modulated by intracellular lipid levels was determined by microarray. (C) Flow cytometry plot and quantification of cell surface MHC-II protein levels in lung macrophages from LysM-Cre × PPARγflox/flox mice (PPARγΔMac/PMN) and controls (CTRL) (n=3-4 mice per group). Heat maps representing mRNA levels of genes involved in macrophage activation (D), lipid signaling (E), oxidative stress signaling (F) and cell death/autophagy (G).