Table 3.
Approximate percentages of organisms showing ultrastructural alterations observed in two H. pylori strains after treatment with polysorbate 80, clarithromycin, metronidazole, polysorbate 80/clarithromycin and polysorbate 80/metronidazole
|
Parameters |
Controls |
Polysorbate 80 |
Clarithromycin |
Metronidazole |
Polysorbate 80/ |
Polysorbate 80/ |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
|
|
|
|
|
|
Clarithromycin |
Metronidazole |
||
| CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | |
| % Altered Shape |
5 |
3 |
90 |
60 |
85 |
50 |
85 |
5 |
100 |
95 |
85 |
80 |
| % Granular Cytoplasm |
1 |
3 |
90 |
70 |
10 |
40 |
5 |
5 |
75 |
60 |
70 |
65 |
| % Altered outer membrane |
1 |
1 |
75 |
75 |
20 |
35 |
20 |
1 |
70 |
75 |
70 |
75 |
| % Presence of “holes” in the cytoplasm |
0 |
0 |
1 |
0 |
40 |
2 |
2 |
1 |
20 |
1 |
1 |
15 |
| % Detachment membrane/cytoplasm |
3 |
1 |
10 |
2 |
30 |
2 |
60 |
2 |
25 |
2 |
50 |
10 |
| % Presence of flagella |
YES |
YES |
NO |
YES |
YES |
YES |
NO |
YES |
YES |
YES |
NO |
NO |
| % Presence of vesicles | - | + | ++ | ++++ | - | ++ | - | + | +/− | ++++ | ++ | ++ |