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. 2012 Oct 11;5:63. doi: 10.1186/1756-8722-5-63

Figure 2.

Figure 2

Selected crosstalk between VEGF and other signaling pathways. VEGF signaling intersects with a number of other signaling pathways, including Ang/Tie, Notch/Dll4, integrins, and hypoxia to orchestrate tumor angiogenesis [26,27,31-35]. Ang = angiopoietin; Dll4 = delta-like ligand 4; HIF = hypoxia-inducible factor; PlGF = placenta growth factor; VEGF = vascular endothelial growth factor; VEGFR = vascular endothelial growth factor receptor. Dashed arrow indicates Ang-2 can serve as a partial Tie-2 agonist under certain conditions.