Table 1.
Cardiovascular risk profiles according to quintiles of UACR in men
| |
UACR, mg/g |
p* |
||||
|---|---|---|---|---|---|---|
|
< 6.50 |
6.5-9.79 |
9.80-13.49 |
13.50-18.89 |
≥ 18.90 |
||
| Number (%) | 691 (22.4) | 692 (22.4) | 641 (20.8) | 549 (17.8) | 511 (16.6) | |
| Age, y |
60.2 ± 8.0 |
61.0 ± 7.9 |
62.3 ± 7.4 |
63.4 ± 7.3 |
63.4 ± 7.2 |
< 0.001 |
| Current smoker, % |
29.8 |
35.0 |
39.6 |
33.4 |
33.1 |
0.287 |
| Current drinker, % |
63.6 |
62.4 |
66.7 |
66.9 |
67.5 |
0.043 |
| Hypertension, % |
31.8 |
33.7 |
33.0 |
41.2 |
47.0 |
< 0.001 |
| Type 2 diabetes, % |
8.0 |
8.7 |
9.8 |
13.5 |
16.3 |
< 0.001 |
| Hyperlipidemia, % |
6.5 |
6.1 |
7.2 |
6.7 |
7.8 |
0.331 |
| Body mass index, kg/m2 |
24.0 ± 2.8 |
23.7 ± 2.7 |
23.8 ± 2.7 |
23.8 ± 2.9 |
24.1 ± 2.8 |
0.059 |
| Waist circumference, cm |
85.5 ± 7.6 |
84.4 ± 7.3 |
85.1 ± 7.8 |
84.7 ± 8.2 |
86.0 ± 7.8 |
0.004 |
| Systolic BP, mmHg |
121.1 ± 15.9 |
122.3 ± 15.1 |
124.3 ± 15.2 |
127.7 ± 16.2 |
129.6 ± 15.9 |
< 0.001 |
| Diastolic BP, mmHg |
79.6 ± 9.3 |
79.6 ± 9.6 |
79.9 ± 9.3 |
81.7 ± 9.9 |
82.1 ± 10.2 |
< 0.001 |
| Total cholesterol, mmol/L |
4.7 ± 0.9 |
4.7 ± 0.9 |
4.7 ± 0.9 |
4.7 ± 0.9 |
4.8 ± 1.0 |
0.246 |
| Triglycerides, mmol/L |
1.8 ± 1.4 |
1.7 ± 1.3 |
1.8 ± 1.3 |
1.8 ± 1.3 |
2.0 ± 1.4 |
< 0.001 |
| HDL cholesterol, mmol/L |
1.2 ± 0.3 |
1.2 ± 0.3 |
1.2 ± 0.3 |
1.2 ± 0.3 |
1.2 ± 0.3 |
0.727 |
| FBG, mmol/L |
5.7 ± 0.9 |
5.7 ± 0.9 |
5.7 ± 1.0 |
5.8 ± 1.1 |
6.1 ± 1.6 |
< 0.001 |
| HOMA-IR |
1.4 ± 1.3 |
1.2 ± 1.1 |
1.3 ± 1.4 |
1.2 ± 1.0 |
1.6 ± 1.9 |
< 0.001 |
| Serum creatinine, μmol/L |
91.5 ± 16.7 |
87.9 ± 13.3 |
87.4 ± 13.1 |
86.0 ± 13.6 |
86.9 ± 13.6 |
< 0.001 |
| eGFR, ml/min/1.73m2 | 83.9 ± 13.0 | 86.9 ± 14.3 | 87.0 ± 14.0 | 88.5 ± 15.4 | 87.1 ± 14.1 | < 0.001 |
Data are expressed as mean ± standard deviation, unless otherwise indicated. BP, blood pressure; HDL; high-density lipoprotein, FBG, fasting blood glucose; HOMA-IR; homeostatic model assessment for insulin resistance, eGFR; estimated glomerular filtration rate.
eGFR was calculated using the 6-variable Modification of Diet in Renal Disease (MDRD) formula.
* p-values for analysis of variance (ANOVA) and chi-square tests for trends are shown, as appropriate.