Skip to main content
. 2013 Jan 4;8(1):e53122. doi: 10.1371/journal.pone.0053122

Figure 7. Schematic representation of suggested protein interactions with LMX1B.

Figure 7

(A) Interactions were identified by means of immunoprecipitation experiments. Direct interactions between NURR1 and PSF, between PSF and LMX1B and between PSF and PSPC1 were found. (LMX1B)-HIS interaction with PSPC1 was identified in a 230 kDa complex only. (B) Western analysis revealed interactions between PSF, PSPC1 and LMX1B at 230 kDa, suggesting a complex of this size containing all three proteins. (C) The Nurr1 transcriptional complex (adapted from [20]. We hypothesize that LMX1B might have a function in this complex as well, by physically binding to PSF, maybe via PSPC1. (D) Novel direct interactors of LMX1B identified in a screen in which IP experiments were analyzed on silver-stained protein gels and by mass-spectrometry analysis.