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Anti-Ad5 immunity suppresses immune responses elicited by rAd5-Env. Groups of mice (four mice per group) in either the absence (A) or presence (B) of anti-Ad5 immunity were immunized with 109 or 107 vp of rAd5-Env vaccine. Vaccine-elicited cellular immune responses were assessed by Dd/P18 tetramer binding to CD8+ T lymphocytes. Anti-Ad5 immunity was induced by preimmunizing mice with 1010 vp of rAd5-Empty 4 weeks prior to rAd5-Env immunization.
