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Effect of teplizumab on C-peptide responses and insulin use in young (age <15 years) and older (>15 years) participants. The C-peptide levels at 6 and 12 months after enrolment, adjusted for baseline C-peptide and HbA1c levels, are shown (mean± 95% CI) for participants treated with teplizumab (black bar) and placebo (white bar). (a) Age 8–14 (teplizumab-treated n=18, placebo–treated n=20) and (b) >15 years (teplizumab-treated n=13, placebo-treated n=7) (*p<0.05, teplizumab vs placebo)
