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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Mol Model. 2012 Aug 29;19(1):371–382. doi: 10.1007/s00894-012-1555-4

Table 1.

Sequence alignment of residues around active site of the three protein kinases, PIM1, GSK3, and CDK2

Kinase N-terminal lobe Linker region C-terminal lobe
PIM-1 L44 G45 S46 F49 V52 A65 I104 L120a E121 R122 – P123 E171 L174 I185a D186
GSK-3β I62 G63 N64 F67 V70 A83 V110 L132a D133 Y134 V135 P136 Q185 L188 C199a D200
CDK2 I10 G11 E12 Y15 V18 A31 V64 F80a E81 F82 L83 H84 Q131 L134 A144a D145
a

Significantly different residues