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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Psychopharmacology (Berl). 2012 Aug 25;225(2):441–451. doi: 10.1007/s00213-012-2833-7

Table 2.

Methadone dose by trimester of pregnancy and postpartum

Methadone Dose N Mean Median Range
Women who converted during or before the first trimester a
 Peak dose 1st trimester 14 70.4 57.5 30-145
 Peak dose 2nd trimester 14 93.4 89 50-155
 Peak dose 3rd trimester/delivery 14 111.7 114 50-180
Women who converted during the second trimester b
 Peak dose 2nd trimester 7 90 80 60-135
 Peak dose 3rd trimester/delivery 7 111.4 100 75-200
Women who converted during the third trimester
 Peak dose 3rd trimester/delivery 4 46.3 45 20-75
Dose 3 to 6 months postpartum c 22 106 97.5 26-190
a

Paired t-test for dose in 1st trimester to 2nd trimester, t(13)=5.45, p=0.0001.

Paired t-test for dose on 2nd trimester to 3rd trimester, t(13)=4.15, p=0.001.

b

Paired t-test for dose on 2nd trimester to 3rd trimester, t(6)=2.35, p=0.06

c

Paired t-test of 3rd trimester and postpartum dose levels, t(21)=0.05, p=0.96.