Table 4.
SNPs with the strongest effects on DRC from the joint analysis
| SNP | Gene Symbol | Chr. | Location | A1/A2 | MAFa | Genotypeb | Test Model | GWAS | Replication | Combined | Pc | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||||||
| GWAS | Replication | GWAS | Replication | Combined | P | P | P | |||||||
| rs13181 | ERCC2/XPD | 19 | coding | C/A | 0.3613 | 0.3681 | 727/812/235 | 563/608/201 | 1290/1420/436 | ADD | 0.02549 | 5.39E-06 | 9.08E-07 | 0.3167 |
| rs9390123 | PHACTR2 | 6 | intron | A/G | 0.3957 | 0.3873 | 639/866/269 | 518/644/209 | 1157/1510/478 | ADD | 0.000025 | 0.02364 | 6.68E-06 | 0.1661 |
| rs7443927 | DUSP1 | 5 | Flanking_3UTR | A/C | 0.1088 | 0.1159 | 1411/340/23 | 1072/282/18 | 2483/622/41 | ADD | 0.001225 | 0.03202 | 0.000176 | 0.2565 |
a
MAF: Minor allele (A1) frequency
b
Wild type homozygote/Heterozygote/Variant homozygote; Two were missing for rs13181, three were missing for rs9390123, and two were missing for rs7443927.
c
P For heterogeneity