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. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: Int J Obes (Lond). 2012 Sep 11;37(6):835–842. doi: 10.1038/ijo.2012.138

Three-dimensional plots for leptin as a function of BMI and apnea-hypopnea index (AHI) for a) non hypertensive (n = 249) and b) hypertensive subjects (n = 199). The significance of associations between leptin levels and sleep apnea severity, obesity and their interaction are shown below the figures. For non hypertensive subjects, a significant association of obstructive sleep apnea (OSA) and obesity with leptin levels is found. Also an OSA by obesity interaction is found with greater association of OSA and leptin in leaner subjects. In hypertensive subjects, no association with OSA is found. All plots are adjusted for gender.

Three-dimensional plots for leptin as a function of BMI and apnea-hypopnea index (AHI) for a) non hypertensive (n = 249) and b) hypertensive subjects (n = 199). The significance of associations between leptin levels and sleep apnea severity, obesity and their interaction are shown below the figures. For non hypertensive subjects, a significant association of obstructive sleep apnea (OSA) and obesity with leptin levels is found. Also an OSA by obesity interaction is found with greater association of OSA and leptin in leaner subjects. In hypertensive subjects, no association with OSA is found. All plots are adjusted for gender.