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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Mol Med (Berl). 2012 Oct 24;91(1):25–36. doi: 10.1007/s00109-012-0968-y

Figure 1. TRAIL induces MR clustering in mouse CAECs via DR4 receptor.

Figure 1

(A) Representative confocal images showing TRAIL induced clustering of MR markers ganglioside GM1, which were detected by cholera toxin subunit B (CTXB). (B) Summarized data showing the dose-dependent effect of TRAIL (0–100 ng/ml) on MR clustering in Smpd1+/+ CAECs (n=6). (C) Confocal microscopy of Smpd1+/+ CAECs revealed a co-localization of DR4 but not DR5 with MR clusters upon TRAIL stimulation. (D) Summarized data showing the co-localization between MRs and DR4 or DR5 in mouse Smpd1+/+ CAECs. *P < 0.05 vs. control (n=6).