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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Mol Med (Berl). 2012 Oct 24;91(1):25–36. doi: 10.1007/s00109-012-0968-y

Figure 4. Reduction of TRAIL-induced O2−· production in ASM-deficient CAECs.

Figure 4

CAECs were stimulated with or without TRAIL and then incubated with O2−· -specific spin trap 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) to form more stable free radicals (CMH-O2−·), which was immediately analyzed by electron spin resonance spectrometry (ESR). Summarized data showing the effect of TRAIL on O2−· production in Smpd1+/+ and Smpd1−/− CAECs., *P < 0.05 vs. Smpd1+/+ control; #P < 0.05 vs. Smpd1+/+ TRAIL (n=6).