Table 3.
Sorafenib first-dose pharmacokinetic parameters.
| Dose (mg/m2 ) |
n | Ka (h−1) | Cmax (mg/L) | Tmax (h) | AUC0–12h (mg*h/L) |
AUC0–24h (mg*h/L) |
t1/2 (h) | CL/F (mL/min/m2) |
|---|---|---|---|---|---|---|---|---|
| 90 | 11 | 0.10 (0.038 – 0.72) | 1.1 (0.35 – 2.5) | 8.7 (3.4 – 17) | 10 (2.5 – 24) | 20 (6.6 – 41) | 5.5 (0.73 – 113) | 44 (7.0 – 146) |
| 110 | 4 | 0.093 (0.080 – 0.15) | 1.6 (0.92 – 2.4) | 11 (8.2 – 14) | 14 (8.0 – 20) | 30 (16 – 47) | 10 (3.9 – 12) | 39 (25 – 80) |
Values are the median (range).
Abbreviations: AUC0–12h, area under the plasma concentration-time curve from time zero to 12 hours; AUC0–24h, area under the plasma concentration-time curve from time zero to 24 hours; Cmax, maximum plasma concentration; CL/F, apparent oral clearance; Ka, absorption rate constant; Tmax, time to maximum plasma concentration; t1/2, half-life.