Table 4.

Sorafenib and sorafenib N-oxide steady-state concentrations.

		Sorafenib Ctrough (mg/L)			Sorafenib N-oxide Ctrough (mg/L)			N-oxide metabolic ratio
Dose (mg/m2)	n	Day 7	Day 13	Day 21	Day 7	Day 13	Day 21	Day 7	Day 13	Day 21
90	13	3.5 (1.2 – 14.4)	2.5 (1.2 – 15.7)	4.8 (1.1 – 11.7)	0.50 (0.11 – 4.5)	0.54 (0.17 – 3.4)	0.72 (0.17 – 4.0	0.14 (0.066 – 0.31)	0.21 (0.12 – 0.37)	0.20 (0.11 – 0.34)
110	4	3.0 (3.0 – 3.5)	2.1 (1.4 – 4.9)	1.6 (1.4 – 5.7)	0.57 (0.37 – 1.5)	0.37 (0.33 – 0.92)	0.40 (0.20 – 0.78)	0.18 (0.12 – 0.49)	0.19 (0.18 – 0.23)	0.14 (0.12 – 0.29)

Values are the median (range).