Table 1.
Prevalence of β-thalassemia and other haemoglobinopathies in six cities of India
| Sr no | Name of the city | Number screened | β-Thal trait, no. (%) | δβ Thal trait, no. (%) | HPFH trait, no. (%) | HbS trait, no. (%) | HbD trait, no. (%) | HbE trait, no. (%) | HbS homozygous, no. (%) | HbE homozygous, no. (%) | HbE-β-Thal, no. (%) | HbS-β-Thal, no. (%) | Other haemoglobino pathies |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bangalore | 9,981 (95%CI) | 216 (2.16 %) | 13 (0.13 %) | 39(0.39 %) | 20 (0.20 %) | 19 (0.19 %) | 13 (0.13 %) | 7 (0.07 %) | 3 (0.03 %) | 1 (0.01 %) | 6 (0.06 %) | HbD-homozygous, 2; othersa, 1 |
| (1.87–2.45) | (0.06–0.2) | (0.27–0.51) | (0.11–0.29) | (0.1–0.28) | (0.06–0.2) | (0.02–0.12) | (0–0.06) | (−0.01–0.03) | (0.01–0.14) | ||||
| 2 | Kolkata | 9,990 (95%CI) | 364 (3.64 %) | 2 (0.02 %) | 13 (0.13 %) | 14 (0.14 %) | 20 (0.2 %) | 392 (3.92 %) | 1 (0.01 %) | 12 (0.12 %) | 9(0.09 %) | – | HbD-β-thal, 1; HbD-homozygous, 1; othersa, 14 |
| (3.23–3.97) | (−0.01–0.05) | (0.06–0.2) | (0.07–0.21) | (0.11–0.29) | (3.52–4.28) | (−0.01–0.03) | (0.5–0.19) | (0.03–0.15) | |||||
| 3 | Dibrugarh | 6,816 (95%CI) | 101 (1.48 %) | 5 (0.73 %) | 12 (0.18 %) | 9 (0.13 %) | 1 (0.02 %) | 1,629 (23.9 %) | 0 | 363 (5.33 %) | 98 (1.44 %) | 3 (0.04 %) | – |
| (1.21–1.79) | (0.53–0.93) | (0.08–0.28) | (0.04–0.22) | (−0.01–0.05) | (22.99–25.01) | (4.77–5.83) | (1.12–1.68) | (−0.01–0.09) | |||||
| 4 | Ludhiana | 9,991 (95%CI) | 375 (3.96 %) | 2 (0.02 %) | 0 | 6 (0.06 %) | 109 (1.09 %) | 4 (0.04 %) | 0 | 1 | 0 | 0 | HbD-β-thal, 2; HbD- homozygous, 3; othersa, 25 |
| (3.62–4.38) | (−0.01–0.05) | (0.01 −0.11) | (0.9–1.3) | (0–0.08) | |||||||||
| 5 | Mumbai | 10,011 (95%CI) | 255 (2.55 %) | 7 (0.07 %) | 20 (0.2 %) | 53 (0.53 %) | 21 (0.21 %) | 13 (0.13 %) | 0 | 0 | 0 | 0 | Othersa, 9 |
| (2.29–2.91) | (0.02–0.12) | (0.11–0.29) | (0.39–0.67) | (0.12–0.3) | (0.06–0.2) | ||||||||
| 6 | Vadodara | 9,991 (95%CI) | 268 (2.68 %) | 6 (0.06 %) | 9 (0.09 %) | 294 (2.94 %) | 34 (0.34 %) | 12 (0.12 %) | 14 (0.14 %) | 0 | 1 | 0 | HbD-β-thal, 2; HbD-homozygous, 3; othersa, 9 |
| (2.38–3.02) | (0.01–0.11) | (0.03–0.15) | (2.57–3.23) | (0.23–0.45) | (0.05–0.19) | (0.07–0.21) | |||||||
| Total | 56,780 (95%CI) | 1,579 (2.78 %) | 35 (0.06 %) | 93 (0.16 %) | 396 (0.70 %) | 204 (0.36 %) | 2,063 (3.63 %) | 22 (0.04 %) | 379 (0.67 %) | 108 (0.19 %) | 9 (0.02 %) | HbD–homozygous, 7; HbD-β–thal, 4; othersa, 58 | |
| (2.66–2.94) | (0.04–0.08) | (0.13–0.19) | (0.63–0.77) | (0.26–0.34) | (3.45–3.75) | (0.02–0.06) | (0.6–0.74) | (0.15–0.23) | (0.01–0.03) |
aOthers—HbD—Iran, HbQ—India and Hb—Lepore trait