Skip to main content
. 2013 Jan;182(1):192–205. doi: 10.1016/j.ajpath.2012.09.007

Figure 8.

Figure 8

Attenuated skin fibrosis in TLR4-mutant mice. C3H/HeJ and WT mice, in parallel, received daily s.c. injections of PBS or bleomycin (Bleo) for up to 21 days. Mice were sacrificed, and lesional skin was examined. A: Left panel: H&E stain. Scale bar = 200 μm. Middle panel: Masson’s Trichrome stain. Scale bar = 200 μm. Right panel: Dermal thickness. Results are the mean ± SD of triplicate determination from five mice per group. Open bars, PBS; closed bars, Bleo. B: Picrosirius red stain, viewed under polarized light. Original magnification, ×100. C: Immunofluorescence images are shown. Red arrows, α-SMA–positive cells. *P < 0.05. Original magnification, ×400.