TABLE 2.

Competitive Binding of NDP-α-MSH, MSH(4), and Compounds 2–5 to hMC4R^a

compd	IC50	n
NDP-α-MSH	5.86 ± 1.90 nM	5
2	1.45 ± 0.44 nM	6
4	3.62 ± 0.86 nM	6
MSH(4)	1.15 ± 0.53 μM	4
3	0.37 ± 0.12 μM	6
5	0.42 ± 0.22 μM	6

^aThe IC₅₀ value given is the average of n independent binding experiments, each done in quadruplicate.