Table 1.

Dot/Icm effectors involved in the modulation of host innate immunity

Effectors (Lpg number)	synonym	Biochemical activity	Targeted host function	Role in innate immunity	Reference
Lpg2464	SidM/Drr A	GEFa/GDF/AMPyl ator	Vesicle trafficking	Membrane remodeling	Machner et al., 2006, Murata et al., 2006, Machner et al., 2007, Muller et al., 2010)
Lpg2464	LepB	GAP	Vesicle trafficking	Membrane remodeling	(Ingmundson et al., 2007)
Lpg2465	SidD	DeAMPylase	Vesicle trafficking	Membrane remodeling	(Neunuebel et al., 2011, Tan et al., 2011)
Lpg0695	AnkX/Leg A8	PC transferase	Vesicle trafficking	Membrane remodeling	(Mukherjee et al., 2011)
Lpg1950	RalF	GEF	Vesicle trafficking	Membrane remodeling	(Nagai et al., 2002)
Lpg2155	SidJ	Unknown	Vesicle trafficking	Membrane remodeling	(Liu et al., 2005)
Lpl2066	LegK2	Protein kinase	Vesicle trafficking	Membrane remodeling	(Hervet et al., 2011)
Lpg0968	SidK	Unknown	v-ATPase	Vacuolar acidification	(Xu et al., 2010)
Lpg1483	LegK1	Protein kinase	NFκ-B activation	Cell survival/immu ne response	(Ge et al., 2009)
Lpg2527	LnaB	Unknown	NFκ-B activation	Cell survival/immu ne response	(Losick et al., 2010)
Lpg0376	SdhA	Unknown	Cell death and IFN induction	Cell survival/immu ne response	(Laguna et al., 2006, Monroe et al., 2009)
Lpg1368	Lgt1	glucosyltransferase	Protein translation	immune response	(Belyi et al., 2006, Fontana et al., 2011)
Lpg2862	Lgt2	glucosyltransferase	Protein translation	immune response	(Belyi et al., 2008, Fontana et al., 2011)
Lpg1488	Lgt3	glucosyltransferase	Protein translation	immune response	Belyi et al., 2008, Fontana et al., 2011)
Lpg2504	SidI	Unknown	Protein translation	immune response	(Shen et al., 2009, Fontana et al., 2011)
Lpg0437	SidL	Unknown	Protein translation	immune response	(Fontana et al., 2011)

^aNote: GEF, guanosine exchange factor

GDF, GDI-displacement factor (GDF)

GAP

GTPase activation protein