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. Author manuscript; available in PMC: 2013 Jan 6.
Published in final edited form as: J Immunol. 2010 Dec 6;186(1):19–23. doi: 10.4049/jimmunol.1002735

Figure 4. Involvement of iOPN in activating signal transduction triggered by zymosan.

Figure 4

(A) Expression of IL-1β and IL-10 by WTand Opn−/− macrophages stimulated with (indicated as “Z”) or without (indicated as “N”) 100 μg/ml zymosan for 24 hr. Macrophage culture supernatants were analyzed by ELISA. (B) Induction of IL-1β and IL-10 production by lentiviral iOPN expression by Opn−/− macrophages with zymosan stimulation. (C) Reduction of phospho-ERK (pERK) in zymosan-stimulated Opn−/−macrophages. (D) Induction of zymosan–induced ERK activation in Opn−/− macrophages by lentiviral iOPN expression.