Table 4.

Influence of quercetin-rich food intake (T3-vs-T1) on family of functional^a miR, stratified by histology and smoking status

Family	miRNA members	Adenocarcinoma		Squamous Cell Carcinomas
Function		Former	Current	Former	Current
		P-value*	P-value*	P-value*	P-value*
Let-7 family	hsa-miR-let-7a	P <0.001	P =0.426	P =0.366	P =0.988
Tumor suppressor	hsa-miR-let-7b
	hsa-miR-let-7c
	hsa-miR-let-7d
	hsa-miR-let-7e
	hsa-miR-let-7f
	hsa-miR-let-7g
	hsa-miR-let-7i
	hsa-miR-98
	hsa-miR-202
miR-146 family	hsa-miR-146a	P =0.002	P =0.092	P =0.753	P =0.222
Tumor growth and invasion	hsa-miR-146b
miR-26 family	hsa-miR-26a	P =0.010	P =0.623	P =0.588	P =0.664
Apoptosis	hsa-miR-26b
miR-17 family	hsa-miR-20a	P =0.031	P =0.943	P =0.766	P =0.283
Tumor progression	hsa-miR-20b
	hsa-miR-106a
	hsa-miR-106b
	hsa-miR-17-5p
	hsa-miR-93
miR-29 family	hsa-miR-29a	P =0.064	P =0.373	P =0.886	P =0.137
DNA methylation	hsa-miR-29b
	hsa-miR-29c
miR-18 family	hsa-miR-18a	P =0.705	P =0.220	P =0.156	P =0.392
Tumor progression	hsa-miR-18b
miR-34 family	hsa-miR-34a	P =0.142	P =0.649	P =0.275	P =0.568
Tumor suppressor	hsa-miR-34c
miR-19 family	hsa-miR-19a	P =0.072	P =0.991	P =0.608	P =0.103
Tumor progression	hsa-miR-19b
miR-15/16 family	hsa-miR-503	P =0.286	P =0.073	P =0.307	P =0.763
Apoptosis	hsa-miR-15a
	hsa-miR-16
	hsa-miR-195
	hsa-miR-424

NOTE: Only results of miR families that had at least one miR that were significant at p-value <0.05 from individual-based miR analyses (Table 2); Bolded p-values indicated results that remained significant after Bonferroni correction for multiple comparisons

Models adjusted for age, sex, BMI, non-quercetin-rich fruits and vegetables, red/processed meat, alcohol, and cigarette packyears.

^aRefer to Supplemental Table S5 for more detailed functions

^*P-value based on Functional Class Score as described in the Methods section