Fig. 4.
Activation of 5-HT2ARs increases the RDD of the H reflex. (A) Hmax responses evoked in adult rats after SCI before (Left) and 7 min after i.p. injection of TCB-2 (0.3 mg/kg) (Right). Each trace is the mean response to 17 consecutive stimulations (the first three discarded) at 0.1, 0.5, 1, 2, or 5 Hz. (B) Time course of the change in H-reflex depression after i.p. injection of vehicle (NaCl; n = 6 rats) or TCB-2 (n = 4). (C) Mean relative amplitudes of the H reflex before (black) and after (blue, 7 min; red, 22 min) the injection of vehicle (Left) or TCB-2 (Right). The data of all experiments are represented (the dots that are slightly offset at each frequency of stimulation are for clarity) together with the one-phase exponential decay fit of these data. ***P < 0.001, comparison of the fits before and after TCB-2 (either 7 or 22 min). The fits before and after vehicle are not significantly different.