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. 2012 Dec 17;110(1):282–287. doi: 10.1073/pnas.1206587110

Fig. 2.

Fig. 2.

IL-33 drives hookworm infection-induced IL-13 production from ILC2s and CD4+ T cells during a primary response. (A) TI/ST2 expression and percentage of intracellular IL-13 within lung ILC2s of WT and IL-33KO mice at the indicated time points following infection with 750 N. brasiliensis L3. Representative plots are shown. (B) Total numbers of lung IL-13+ ILC2s (Upper) and lung IL-13+CD4+ TCRβ+ cells (Lower) from WT and IL-33KO mice at the indicated time points following infection with 750 N. brasiliensis L3. Data shown represent the mean ± SE of 4–6 mice/group analyzed from three independent experiments. (C) IL-4 and IL-13 mRNA levels in sorted ILC2s (Upper) and CD4 T (Lower) from WT and IL-33KO mice 6 d following 750 L3 infection. *P < 0.05, **P < 0.01, and ***P < 0.001.