Fig. 3.
IL-33 is required for IL-13 production, RELMβ expression and pulmonary pathogenesis during primary infection with N. brasiliensis . RELMβ mRNA transcript levels in the (A) lung and (B) jejunum at the indicated time points following infection with 750 N. brasiliensis L3. IL-13 mRNA levels in the (C) lung and (D) gut at indicated time points postinfection. Data shown represent the mean ± SE of 6–12 mice/group analyzed from two independent experiments. (E) Total numbers of eosinophils and (F) red blood cells within the BAL fluid in WT and IL-33KO mice at d 3 and d 6 following 750 L3 infection. Data shown represent the mean ± SE of 4–6 mice/group analyzed from three independent experiments. *P < 0.05 and **P < 0.01.