Figure 4.

Fusion between the secondary palate and the nasal septum in mouse embryos. (a–d) A wild-type mouse embryo (E18.5) that had been injected with Ad-GFP at E14.5 shows that the secondary palate is fused with the nasal septum anteriorly. (e–h) A Tgfβ3^−/− mouse rescued with a palatal fusion score of 12 shows vertical fusion with the nasal septum similar to wild-type mice infected with Ad-GFP. (i–l) An example of a complete failure to fuse with the nasal septum is shown in a Tgfβ3^−/− mouse rescued with a palatal fusion score of 12. (m) A diagram is shown to indicate where the histological sections were obtained. GFP, green fluorescent protein; TGFβ3, transforming growth factor β3.