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. 2012 Oct 2;21(1):185–191. doi: 10.1038/mt.2012.180

Figure 5.

Figure 5

Inhibition of breast cancer development in vivo using GE11-positive exosomes containing let-7a. Human embryonic kidney cell line 293 (HEK293) cells expressing GE11 were transfected with synthetic let-7a. Exosomes containing let-7a were purified from culture supernatants and intravenously injected (1 µg of purified exosomes, once per week for 4 weeks) into mice bearing luciferase-expressing HCC70 cells. (a) Let-7a levels in the purified exosomes were measured using quantitative PCRs. Data are expressed as means ± SD. n = 3. (b) Representative images of tumors 4 weeks postinjection are shown. (c) Luciferase signals from the tumors were measured using an in vivo imaging system (IVIS). Data are expressed as means ± SD. n = 5; *P < 0.05.