Figure 5.

Wnt signaling stimulates proplatelet production in fetal liver MKs ex vivo. (A) Percentage of cultured MKs extending proplatelets in cells treated with Wnt3a, Wnt5a, and DKK1. Data are presented as mean ± SD from 3 individual experiments. P values and significance have been determined by 1-way ANOVA followed by Dunnett posttest to compare all groups with untreated cells. (B-D) Representative images of proplatelet-producing MKs in untreated, Wnt3a, and Wnt5a treated samples, respectively.