Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
General PK/PD paradigm that accounts for the primary factors governing the effects of most anti-inflammatory agents. The pharmacokinetics, target site drug distribution, mechanisms of drug action, inflammatory provocation processes, resultant mediators or biomarkers, and target tissues are primary components needing recognition in most models.
