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PK/PD modeling of antinociceptive effects (dysfunction index) of tolmetin in rats, adapted from Ref. 59. Top panel shows the model schematic used for fitting of data. Lower panels show PK/PD time profiles of tolmetin in selected rats. Open circles are tolmetin blood concentrations and closed circles are dysfunction index values (%). The panels indicate doses of (a) 1, (b) 3.2, (c) 10, (d) 31.6, (e) 56.2, and (f) 100 mg/kg tolmetin given orally to the rats.
