TABLE 3.
Analysis of the TRMT11 Gene and Its Corresponding SNPs in Relation to Time to ADT Failure in 304 Study Patients
| TRMT11 SNP marker | Time to ADT failure, median (IQR) (y) |
P value (Spearman correlation coefficient) | ||
|---|---|---|---|---|
| Minor allele=0 | Minor allele=1 | Minor allele=2 | ||
| rs1268121 | 3.05 (1.42-5.02) | 4.27 (1.75-9.49) | 6.22 (3.62-13.17) | .002 (0.18) |
| rs2326215 | 3.01 (1.41-5.87) | 3.56 (1.64-6.29) | 3.85 (2.26-7.02) | .09 (0.09) |
| rs6569442 | 3.01 (1.41-5.87) | 3.56 (1.64-6.29) | 3.85 (2.26-7.02) | .09 (0.09) |
| rs6900796 | 2.42 (1.36-4.26) | 3.52 (1.51-6.48) | 4.18 (2.33-7.33) | <.001 (0.20) |
ADT = androgen deprivation therapy; IQR = interquartile range; SNP = single-nucleotide polymorphism.