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(a) A variety of azole structures, including clotrimazole, fluconazole, voriconazole and itraconazole (medical antifungal drugs) and the agrochemical demethylase inhibitors prochoraz, triadimenol, epoxyconazole and prothioconazole. (b) The molecular model of triadimenol bound to M. graminicola CYP51 with locations of resistance residues Y137 and I381. (c) Ergosterol biosynthesis from lanosterol highlighting the 14α-methyl group removed by CYP51.
