TABLE 2.
Hazard Ratios for All-Cause and Cardiovascular Disease Mortality in Men With Documented or Suspected Coronary Heart Diseasea
| Characteristic | No. of patients | No. of deaths |
All-cause mortality |
CVD mortality |
|||
|---|---|---|---|---|---|---|---|
| All-cause | CVD | Model 1b | Model 2c | Model 1b | Model 2c | ||
| CRF | |||||||
| Low | 3193 | 354 | 190 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Middle | 3170 | 209 | 88 | 0.72 (0.60-0.86) | 0.69 (0.58-0.83) | 0.59 (0.46-0.77) | 0.58 (0.45-0.76) |
| Upper | 3200 | 170 | 70 | 0.65 (0.54-0.80) | 0.60 (0.48-0.74) | 0.54 (0.40-0.73) | 0.51 (0.37-0.70) |
| BMI (kg/m2) | |||||||
| 18.5-24.9 | 3286 | 303 | 131 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 25-29.9 | 4648 | 314 | 159 | 0.82 (0.70-0.97) | 0.73 (0.61-0.86) | 0.96 (0.76-1.22) | 0.80 (0.63-1.03) |
| 30-34.9 | 1317 | 91 | 42 | 0.99 (0.78-1.27) | 0.80 (0.62-1.03) | 1.03 (0.72-1.47) | 0.76 (0.52-1.10) |
| ≥35 | 312 | 25 | 16 | 2.07 (1.36-3.16) | 1.42 (0.91-2.21) | 3.31 (1.92-5.72) | 1.93 (1.08-3.45) |
| Body fat (%) | |||||||
| Low (<20) | 3228 | 240 | 101 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Middle (20-25) | 3115 | 222 | 113 | 0.86 (0.72-1.03) | 0.76 (0.63-0.92) | 1.03 (0.78-1.35) | 0.87 (0.66-1.14) |
| Upper (>25) | 3220 | 271 | 134 | 0.97 (0.81-1.16) | 0.77 (0.63-0.93) | 1.08 (0.83-1.42) | 0.78 (0.58-1.03) |
| Waist circumference (cm) | |||||||
| Low (<90) | 3341 | 264 | 114 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Middle (90-98) | 3073 | 218 | 105 | 0.82 (0.68-0.98) | 0.74 (0.61-0.89) | 0.91 (0.69-1.19) | 0.79 (0.60-1.04) |
| Upper (>98) | 3149 | 251 | 129 | 0.95 (0.79-1.14) | 0.76 (0.63-0.93) | 1.11 (0.85-1.45) | 0.81 (0.61-1.08) |
a
BMI = body mass index; CHD = coronary heart disease; CRF = cardiorespiratory fitness; CVD = cardiovascular disease.
b
Adjusted for age, baseline examination year, physical activity (active or inactive), smoking (current smoker or not), alcohol intake (>14 drinks/wk or not), hypercholesterolemia, hypertension and diabetes (present or not for each), and family history of CVD.
c
All variables in model 1 plus BMI, body fat, and waist circumference (as continuous variables) for CRF, or CRF (as a continuous variable) for BMI, body fat, and waist circumference.