TABLE 2.

Results of LAMP

Reference, year	Reference Standard	No. of studies	Sensitivity	Specificity	Notes
Kato et al,38 2005	Cytotoxicity assay	74	0.97	0.71	Authors attribute high false-positive rate to superiority of LAMP, eg, more sensitive than cytotoxicity assay
Lalande et al,39 2011	Toxigenic culture	472	0.92	0.99	Study indicates LAMP to be more sensitive than cytotoxicity assay, to which it was compared
Doing and Hintz,37 2012	Agreement with ProGastro PCR test	446	0.98	0.99	Cases without agreement tested with cytotoxicity assay
Boyanton et al,35 2012	Agreement between 4 different molecular tests for CDI	139	0.95	0.97	Unresolved cases tested with toxigenic culture
Norén et al,40 2011	Toxigenic culture	272	0.98	0.98	…
Ota and McGowan,36 2012	Cytotoxicity assay	141	0.89	0.98	LAMP tests were performed as part of a 2-step glutamate dehydrogenase assay

LAMP = loop-mediated isothermal amplification; PCR = polymerase chain reaction.