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AEDs Approved in 2009-2011
| AED | FDA indication | Putative mechanism |
|---|---|---|
| Vigabatrin | Infantile spasms/add-on for partial epilepsy | Irreversible inhibition of GABA transaminase |
| Rufinamide | Atonic seizures | Sodium channel modulation |
| Lacosamide | Add-on for partial epilepsy | Sodium channel modulation |
| Clobazam | Lennox-Gastaut syndrome | GABAA binding |
| Ezogabine | Add-on for partial epilepsy | Potassium channel modulation |
AED = antiepileptic drug; FDA = Food and Drug Administration; GABA = γ-aminobutyric acid.
