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a) Representative nitric oxide pathway.b) Effects of aging on nitric oxide pathway. BH4 = tetrahydrobiopterin; Ca2+ = calcium ion; cGMP = cyclic guanosine monophosphate; eNOS = endothelial nitric oxide synthase; GTP = guanosine triphosphate; NADPH = nicotinamide adenine dinucleotide phosphate; NO = nitric oxide; ONOO- = Peroxynitrite; ADMA = Dimethylarginine; ROS = reactive oxygen species.
