Table 6.
MDDR classes that contain higher percentage (≥3%) of SVM virtual-hits and the percentage values
| MDDR Classes that contain higher percentage (≥3%) of virtual hits | No of virtual hits in class | Percentage of class members selected as virtual hits |
|---|---|---|
| Antineoplastic |
623 |
2.9% |
| Tyrosine-Specific Protein Kinase Inhibitor |
231 |
19.6% |
| Signal Transduction Inhibitor |
194 |
9.5% |
| Antiarthritic |
176 |
1.5% |
| Antiallergic/Antiasthmatic |
83 |
0.8% |
| Antihypertensive |
76 |
0.7% |
| Antiangiogenic |
75 |
4.6% |
| Treatment for Osteoporosis |
55 |
2.2% |
| Antidepressant | 49 | 0.8% |
Virtual-hits are identified by SVMs in screening 168K MDDR compounds for Src inhibitors. The total number of SVM identified virtual hits is 1,496.