Panax Ginseng
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Contains ginsenosides which are purported to have anti-inflammatory, antioxidant, and anticancer effects. Purported to enhance perceptions of energy, increase stamina and improve nitrogen balance [96].
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Most well-controlled research does not support the ergogenic effects for ginseng [97-111]. No known effects at dosages found in ED and ES.
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L-Carnitine
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Involved in shuttling long chain fatty acids into mitochondria. Purported to promote lipolysis [112].
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Limited supportive ergogenic value in athletes or on weight loss [112]. No known effects at dosages found in ED and ES.
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D-Ribose
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Involved in ATP synthesis. Theoretically, D-ribose supplementation can increase ATP availability.
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Some evidence of improved exercise capacity in clinical populations [113] but limited evidence that high dose ribose supplementation affects exercise capacity [114-119]. No known effects at dosages found in ED and ES.
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Beta Alanine
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Increases muscle carnosine levels, increases muscle buffering, and attenuates fatigue during high intensity exercise [120-124].
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Growing scientific evidence of improved anaerobic capacity (2-4 g/d) [125-138]. No known effects at dosages found in ED and ES.
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Inositol
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Carbohydrate that is not classified as sugar. Involved in insulin signaling, nerve transmission, serotonin modulation, and fat oxidation [139].
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No known effects at dosages found in ED or ES.
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Citrulline Malate
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Optimizes blood flow via arginine-nitric oxide pathway; purported to reduce fatigue and buffer acidity during exercise [140,141].
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Some evidence that high dosages (e.g., 6 – 8 g) can affect exercise capacity and/or anabolism [142-149]. No known effects at dosages found in ED and ES.
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Quercetin |
Reported to have antioxidant, anti-inflammatory, antiviral, and immune-modulatory effects [150]. |
Several studies indicate that Quercetin supplementation (e.g., 1 g/d for 7 d) increases maximal aerobic capacity and time to fatigue [151-166]. No known effects at dosages found in ED or ES. |