Table 1. Enriched pathways in T2D interactome.
Term | Corrected p value* |
Pathways in cancer | 4.52E-27 |
Prostate cancer | 2.02E-17 |
Chronic myeloid leukemia | 4.90E-17 |
B cell receptor signaling pathway | 3.44E-15 |
Pancreatic cancer | 1.38E-13 |
Glioma | 3.24E-13 |
Focal adhesion | 1.19E-12 |
Proteasome | 3.38E-12 |
Acute myeloid leukemia | 3.15E-12 |
Neurotrophin signaling pathway | 1.39E-11 |
Insulin signaling pathway | 2.57E-11 |
Small cell lung cancer | 2.98E-11 |
T cell receptor signaling pathway | 3.35E-10 |
ErbB signaling pathway | 4.29E-10 |
Non-small cell lung cancer | 4.09E-10 |
Colorectal cancer | 7.45E-09 |
Cell cycle | 9.14E-09 |
Fc epsilon RI signaling pathway | 9.32E-09 |
Type II diabetes mellitus | 2.00E-08 |
Adherens junction | 4.16E-08 |
Melanoma | 3.49E-07 |
Fc gamma R-mediated phagocytosis | 3.46E-07 |
Adipocytokine signaling pathway | 7.42E-07 |
Renal cell carcinoma | 1.42E-06 |
Bladder cancer | 1.72E-06 |
Jak-STAT signaling pathway | 2.82E-06 |
Chemokine signaling pathway | 3.28E-06 |
Endometrial cancer | 3.65E-06 |
Notch signaling pathway | 6.27E-06 |
TGF-beta signaling pathway | 6.48E-06 |
Natural killer cell mediated cytotoxicity | 6.30E-06 |
Aldosterone-regulated sodium reabsorption | 7.51E-06 |
Thyroid cancer | 1.01E-05 |
VEGF signaling pathway | 1.44E-05 |
Progesterone-mediated oocyte maturation | 8.87E-05 |
mTOR signaling pathway | 9.80E-05 |
Leukocyte transendothelial migration | 1.25E-04 |
Oocyte meiosis | 1.57E-04 |
Pathogenic Escherichia coli infection | 2.39E-04 |
Ubiquitin mediated proteolysis | 3.04E-04 |
p53 signaling pathway | 3.29E-04 |
Wnt signaling pathway | 3.97E-04 |
NOD-like receptor signaling pathway | 5.10E-04 |
MAPK signaling pathway | 8.07E-04 |
Regulation of actin cytoskeleton | 0.001 |
Toll-like receptor signaling pathway | 0.002 |
Apoptosis | 0.003 |
Epithelial cell signaling in Helicobacter pylori infection | 0.004 |
Gap junction | 0.01 |
RIG-I-like receptor signaling pathway | 0.02 |
Tight junction | 0.02 |
GnRH signaling pathway | 0.02 |
Long-term depression | 0.04 |
Bejamini-Hochberg correction.