Table 3.
Risk of incident type 2 diabetes mellitus in relation to each haemostatic variable
| |
Crude OR |
Multivariate model 1
*
|
Multivariate model 2
†
|
Multivariate model 3
‡
|
|
|---|---|---|---|---|---|
| n cases/n referents | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| tPA |
153/260 |
2.78 |
1.79 |
1.54 |
1.22 |
| (2.04 - 3.79)§ |
(1.27 - 2.53)§ |
(1.06 - 2.23)§ |
(0.77 - 1.94) |
||
| PAI-1 |
152/260 |
2.35 |
1.86 |
1.61 |
1.60 |
| (1.79 - 3.09)§ |
(1.34 - 2.59)§ |
(1.14 - 2.28)§ |
(1.03 - 2.47)§ |
||
| tPA/PAI-1 complex |
154/262 |
4.05 |
2.92 |
2.45 |
1.70 |
| (2.83 - 5.79)§ |
(1.92 - 4.43)§ |
(1.56 - 3.84)§ |
(1.02 - 2.82)§ |
||
| VWF |
153/261 |
1.78 |
1.43 |
1.33 |
1.33 |
| (1.39 - 2.29)§ | (1.04 - 1.94)§ | (0.95 - 1.85) | (0.88 - 2.02) | ||
Conditional logistic regression analysis performed with complete data sets. ORs with 95% CIs, per 1 SD increment.
* Model 1: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM and physical activity (sedentary/moderate/active).
† Model 2: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides.
‡ Model 3: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides, fasting glucose level and 2 hour capillary glucose level.
§ p < 0.05.
Natural logarithm transformation was used for C-reactive protein, triglycerides, tPA, PAI-1, tPA/PAI-1 complex and VWF.
OR: odds ratio; CI: confidence interval; SD: standard deviation; T2DM: type 2 diabetes mellitus; tPA: tissue plasminogen activator; PAI-1: plasminogen activator inhibitor-1; VWF: von Willebrand factor.