Table 4.
Risk of incident type 2 diabetes mellitus for cases with normal glucose levels * and cases with elevated glucose levels †
| |
Cases with normal glucose levels* |
|
Cases with elevated glucose levels
†
|
|||
|---|---|---|---|---|---|---|
| |
Crude OR |
Multivariate model‡ |
|
Crude OR |
Multivariate model‡ |
|
| n cases/n referents | OR (95% CI) | OR (95% CI) | n cases/n referents | OR (95% CI) | OR (95% CI) | |
| tPA |
59/103 |
2.43 |
1.24 |
94/157 |
3.05 |
1.82 |
| (1.50 - 3.91)§ |
(0.57 - 2.70) |
|
(2.02 - 4.61)§ |
(1.11 - 2.98)§ |
||
| PAI-1 |
57/100 |
2.66 |
2.06 |
95/160 |
2.20 |
1.40 |
| (1.66 - 4.25)§ |
(1.10 - 3.86)§ |
|
(1.57 - 3.07)§ |
(0.89 - 2.20) |
||
| tPA/PAI-1 complex |
59/103 |
3.23 |
1.67 |
95/159 |
4.80 |
4.01 |
| (1.93 - 5.41)§ |
(0.87 - 3.22) |
|
(2.90-7.92)§ |
(1.90 - 8.46)§ |
||
| VWF |
58/102 |
1.66 |
1.43 |
95/159 |
1.86 |
1.35 |
| (1.13 - 2.46)§ | (0.79 - 2.59) | (1.35 - 2.58)§ | (0.87 - 2.09) | |||
* Fasting plasma glucose (FPG) < 6.1 and 2-hour capillary plasma glucose (2hPG) < 8.9 mmol/L.
† FPG 6.1-6.9 and/or 2hPG 8.9-12.1 mmol/L.
Conditional logistic regression analysis performed with complete data sets. ORs with 95% CIs, per 1 SD increment.
‡ Model including body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides and one of the fibrinolytic variables (tPA: tissue plasminogen activator; PAI-1: plasminogen activator inhibitor-1 or tPA/PAI-1 complex).
§ p < 0.05.
Natural logarithm transformation was used for C-reactive protein, triglycerides, tPA, PAI-1 and tPA/PAI-1 complex.
OR: odds ratio; CI: confidence interval; SD: standard deviation.