Table 3. Effect of marital status and CHRNA5 (rs16969968) on the relationship between NEO-PI-R personality domains and CD in AA and EA subjects.

		NEO-PI-R domain and Population
		Neuroticism		Extraversion		Openness to experience		Agreeableness		Conscientiousness
		AAs	EAs	AAs	EAs	AAs	EAs	AAs	EAs	AAs	EAs
Main effect of NEO-PI-R domain	OR (95% CI)	3.00 (2.33–3.88)	2.91 (2.22–3.83)	0.66 (0.53–0.82)	0.54 (0.42–0.68)	0.59 (0.48–0.74)	0.44 (0.34–0.57)	0.51 (0.50–0.52)	0.43 (0.34–0.55)	0.43 (0.35–0.52)	0.30 (0.23–0.39)
	p-value	2.00e-16	1.40e-14	1.70e-04	4.60e-07	3.28e-06	1.65e-10	5.90e-12	4.69e-12	2.00e-16	2.00e-16
Main effect of “Divorced” marital status	OR (95% CI)	1.03 (0.81–1.32)	1.09 (0.89–1.33)	0.96 (0.77–1.21)	0.81 (0.68–0.95)	0.75 (0.60–0.94)	0.76 (0.64–0.91)	1.17 (0.97–1.42)	1.08 (0.91–1.27)	0.94 (0.78–1.13)	0.94 (0.80–1.11)
	p-value	0.780	0.389	0.767	0.011	0.013	2.27e–03	0.100	0.368	0.496	0.475
Main effect of “Married” marital status	OR (95% CI)	0.84 (0.65–1.08)	0.64 (0.51–0.82)	0.86 (0.70–1.05)	0.72 (0.61–0.85)	0.77 (0.63–0.95)	0.62 (0.53–0.74)	1.06 (0.84–1.20)	0.98 (0.83–1.16)	1.03 (0.84–1.28)	0.97 (0.825–1.14)
	p-value	0.180	2.72e-04	0.147	1.21e-04	0.013	4.43e-08	0.947	0.859	0.750	0.736
Main effect of rs16969968	OR (95% CI)	0.77 (0.54–1.09)	1.01 (0.85–1.34)	0.81 (0.64–1.03)	0.95 (0.83–1.10)	0.94 (0.73–1.21)	0.93 (0.80–1.07)	1.01 (0.99–1.03)	0.92 (0.82–1.05)	1.03 (0.81–1.31)	0.80 (0.70–0.91)
	p-value	0.136	0.886	0.083	0.507	0.656	0.317	0.953	0.225	0.795	1.05-03
Interaction between NEO-PI-R domain and “Divorced” marital status	OR (95% CI)	0.92 (0.57–1.51)	0.88 (0.62–1.25)	1.05 (0.67–1.64)	1.65 (1.20–2.26)	1.77 (1.13–2.77)	1.80 (1.29–2.52)	0.71 (0.49–1.03)	0.95 (0.68–1.31)	1.14 (0.79–1.65)	1.16 (0.83–1.62)
	p-value	0.756	0.466	0.845	2.02e-03	0.015	5.24e-04	0.085	0.734	0.499	0.351
Interaction between NEO-PI-R domain and “Married” marital status	OR (95% CI)	1.18 (0.69–1.97)	1.91 (1.24–2.95)	1.09 (0.72–1.65)	1.45 (1.06–1.98)	1.35 (0.88–2.08)	1.90 (1.36–2.64)	0.79 (0.55–1.15)	0.80 (0.57–1.12)	0.75 (0.49–1.15)	0.81 (0.58–1.13)
	p-value	0.505	3.58e-03	0.676	0.020	0.169	1.54e-04	0.239	0.206	0.185	0.218
Interaction between NEO-PI-R domain and rs16969968	OR (95% CI)	1.73 (0.87–3.44)	0.96 (0.72–1.29)	1.58 (0.99–2.53)	1.08 (0.84–1.40)	1.17 (0.70–1.95)	1.90 (1.44–2.49)	1.03 (0.67–1.58)	1.18 (0.92–1.53)	0.95 (0.60–1.53)	1.62 (1.23–2.12)
	p-value	0.111	0.817	0.056	0.534	0.538	0.383	0.887	0.206	0.850	8.94e-04
Interaction between rs16969968 and “Divorced” marital status	OR (95% CI)	1.05 (0.91–1.21)	1.03 (0.96–1.10)	1.00 (0.90–1.12)	1.02 (0.96–1.09)	1.01 (0.90–1.13)	1.03 (0.97–1.10)	1.00 (0.89–1.12)	1.01 (0.94–1.08)	0.97 (0.87–1.09)	1.04 (0.97–1.11)
	p-value	0.464	0.419	0.975	0.500	0.841	0.326	0.981	0.830	0.668	0.299
Interaction between rs16969968 and “Married” marital status	OR (95% CI)	0.98 (0.92–1.04)	1.01 (0.94–1.08)	1.00 (0.89–1.11)	1.03 (0.97–1.09)	1.00 (0.90–1.11)	1.04 (0.98–1.11)	0.96 (0.86–1.08)	1.01 (0.95–1.08)	0.95 (0.85–1.07)	1.03 (0.96–1.10)
	p-value	0.755	0.853	0.951	0.389	0.968	0.193	0.551	0.681	0.407	0.456

Reference group for marital status were subjects who have never been married. Reference group for the genotypes of rs16969968 were subjects who did not have any copies of minor allele. All odds ratios (OR) refer to 10 units change in personality scores, meaning that the presented odds of an individual developing CD reflect the NEO-PI-R domain score change in the magnitude of 10. Presented p-values are not adjusted for multiple testing. Bonferroni-corrected significance threshold was set to 1.67e-03. Significant p-values are highlighted in bold.