Table 2.
Dose and incremental ratios in 81 modified-Fibonacci-sequence designed studies
| |
Planned dose in |
Actual doses |
||||
|---|---|---|---|---|---|---|
| Dose-level (nof studies reaching the dose-level) | Genuine Fibonacci sequence | Modified Fibonacci sequence | Median of actual dose | Min. of actual dose | Max. of actual dose | Mean (± SD) of actual dose |
|
1(81) |
1 |
1.0 |
1 |
- |
- |
- |
|
2(81) |
2 |
2.0 |
2.00 |
0.80 |
10 |
1.82 (0.65) |
|
3 (77) |
3 |
3.3 |
3.00 |
0.80 |
3.33 |
4.08 (1.65) |
|
4 (67) |
5 |
5.1 |
4.00 |
0.97 |
10.00 |
9.23 (3.12) |
|
5 (58) |
8 |
6.60 |
5.32 |
1.20 |
33.33 |
17.61 (4.71) |
|
6 (43) |
13 |
8.80 |
7.80 |
0.90 |
56.25 |
34.49 (6.89) |
|
7 (32) |
21 |
11.8 |
11.93 |
1.86 |
80.00 |
67.96 (9.77) |
|
8 (19) |
34 |
15.6 |
15.78 |
6.67 |
128.00 |
35.64 (5.43) |
|
9 (13) |
55 |
20.8 |
19.50 |
13.33 |
256.00 |
78.11 (8.69) |
|
10 (7) |
89 |
27.8 |
23.00 |
18.00 |
512.00 |
133.38 (12.69) |
|
11 (5) |
144 |
36.8 |
28.89 |
23.50 |
1024.00 |
227.16 (17.85) |
|
12 (3) |
233 |
49.0 |
38.44 |
35.83 |
2048.00 |
707.43 (29.89) |
| 13 (0) | 377 | 65.2 | - | - | - | - |
n: number of studied reaching the specified dose-level; SD: standard deviation.