Table 3. Specified numerical values from the data shown in Fig. 3.a .
| DAPT, nM | activity on Endogenous substrate b (Aβ 1-40 secreted in pM per 106 cells) | Maximal Activity that can be achieved by transfection c (Aβ 1-40 secreted in pM per 106 cells) | Endogenous activity as percentage of maximal activity achieved by transfection d | cDNAwtC99 required to reach maximal activity e (ng/mL) | cDNAwtC99 required to reach activation by DAPTf (ng/mL) |
| 0 | 32.4 | 229.9 | 14.1 | 250.0 | - |
| 33 | 81.1 | 204.5 | 39.7 | 191.0 | 70 |
| 100 | 132.0 | 182.0 | 72.5 | 92.7 | 120 |
| 333 | 129.0 | 140.0 | 92.1 | 59.8 | 118 |
| 500 | 111.6 | 125.0 | 89.3 | 39.2 | 100 |
| 1000 | 43.0 | 44.7 | 96.2 | 14.0 | 16 |
the table shows specified numerical values from the data shown in Fig. 3.
Aβ 1-40 secretion activity in untransfected cells at the specified DAPT concentrations (i.e. activation at 0 ng/ml cDNAwtC99).
maximal Aβ 1-40 secretion activity that can be achieved by the transfections at the specified DAPT concentrations.
percentage ratio between the activity on endogenous substrate and the maximal activity that can be reached by transfections (i.e. the percentage ration between values in columns 2 and 3).
cDNAwtC99 in ng/mL required for transfection to reach maximal Aβ 1-40 secretion activity at the specified DAPT concentration.
cDNAwtC99 in ng/mL that is required in transfections, to reach the same levels of Aβ 1-40 secretion activity as the activation of Aβ 1-40 secretion on endogenous C99 substrate at the specified DAPT concentration.