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. 2013 Jan 7;8(1):e53951. doi: 10.1371/journal.pone.0053951

Figure 6. The content of pyridine nucleotides in FVB and Mb hearts.

Figure 6

(A) The content of NAD in Mb-sham was significantly lower than in FVB-sham. After TAC, NAD content decreased significantly in both FVB and Mb hearts, whereas no significant difference was found between FVB-TAC and Mb-TAC. (B) NADH content was similar in FVB and Mb hearts in sham and TAC groups. (C) The ratio of NADH to NAD was significantly higher in Mb-sham than in FVB sham. After TAC, the ratio in FVB and Mb went up significantly, whereas no significant difference was found when comparing FVB-TAC with Mb-TAC. (D) NADP+ content was lower in Mb-sham compared to FVB-sham. TAC decreased NADP+ content in both FVB and Mb hearts and NADP+ content in Mb-TAC was significantly lower than in FVB-TAC. (E) A significant decrease of NADPH content was observed in FVB and Mb hearts after TAC. The NADPH content was constant in FVB-sham and Mb-sham while no significant difference was found between FVB-TAC and Mb-TAC. (F) TAC increased the ratio of NADPH to NADP+ in Mb but not in FVB hearts. Furthermore, the ratio in Mb-TAC was significantly higher than in FVB-TAC. (G) The ratio of reduced pyridine nucleotides, NADPH plus NADH to oxidized nucleotides, NADP+ plus NAD+ was significantly increased in both FVB and Mb hearts after TAC, and the ratio in Mb-TAC was significantly greater than in FVB-TAC. * indicates p<0.05 for sham vs. TAC; # indicates p<0.05 for Mb-sham vs. FVB-sham or Mb-TAC vs. FVB-TAC by two way ANOVA, n = 8 for Mb-TAC and n = 5 for other groups.