Table 1. Biophysical parameters of WT and I890T channels.

	I Na at −20 mV		Activation			Steady-state Inactivation			Slow inactivation		Recovery from inactivation
	pA/pF	n	V 1/2 (mV)	k	n	V 1/2 (mV)	k	n	τ (ms)	n	τ (ms)	n
WT	−52.0±6.5	15	−32.0±0.3	−6.9±0.3	18	−84.9±0.9	−4.9±0.4	10	243.2±39.9	5–14	3.9±0.1	11
I890T	−35.9±3.4*	22	−27.3±0.3**	−6.7±0.2	22	−84.2±0.4	−4.9±0.4	15	224.2±35.0	5–19	4.2±0.1	16

Activation and steady-state inactivation parameters were calculated by data fitting to Boltzmann functions (see Methods). V_1/2 is the voltage for half-maximal activation or steady-state inactivation and k is the slope factor. Slow inactivation and recovery from inactivation data were fitted to mono-exponential functions (see Methods) to obtain the time constant τ. Values are expressed mean ± SE. *p<0.05; **p<0.01.