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. 2013 Jan 7;8(1):e53300. doi: 10.1371/journal.pone.0053300

Figure 4. RasGRP1 KO and RasGRP1/3 DKO DN4 thymocytes show an increased frequency of γδ T cells, despite normal numbers and frequencies of mature thymic γδ T cells. A.

Figure 4

CD3 by γδTCR profiles of bulk thymocytes from B6 (n = 7), 1KO (n = 3), 3KO (n = 6) and DKO (n = 9) thymi. B. Frequencies and numbers of mature CD3+γδTCR+ γδ T cells. C. left, frequencies of surface TCRβ+ DN4 (CD4−CD8−Thy1.2+CD44−CD25−) cells from B6 (n = 8), 1KO (n = 6), 3KO (n = 9) and DKO (n = 12) thymi; right, frequencies of surface γδTCR+ DN4 cells. ***p<0.001.